Otto-von-Guericke-University Magdeburg
Research Group
Anne Dudeck
Research Group Anne Dudeck
The Dudeck lab explores the intercellular communication of innate immune cells which ensure the first line immune defense and tissue integrity. In different mouse models of inflammatory skin diseases, we study the complex dynamics of tissue resident immune cell responses and cell recruitment processes.
The main focus of our research group is the investigation of mast cells as orchestrators of local inflammatory processes in the skin and their systemic effects. Although mast cells are known to be effector cells of type I allergy, their role in the induction and regulation of innate and adaptive immunity and in maintaining tissue integrity is poorly understood. Our work over the last years has shown that mast cells play an important role as tissue-resident sentinel cells which initiate the innate immune response and can also influence the adaptive defense.
For our work, we apply high-performance methods for both quantitative and qualitative analysis of different immune cell populations, such as elaborate flow cytometry analysis and transcriptomic profiling. In particular, we perform sophisticated imaging analysis, such as intravital 2-photon microscopy and light sheet microscopy of transgenic mouse models, in which certain cells express fluorescent reporter proteins. Most notably, the non-invasive intravital microscopy of the skin enables us to track immune cell motilities and interaction in real time and study the course of an inflammatory response up to tissue regeneration. Moreover, we use mouse models of conditional gene inactivation to decipher the relevance of certain mast cell mediators or signaling compenents.
Coming up!
08/2025
The next Summer School of the RTG 2408 is coming up! From August 11-14, 2025 there will be a variety of different events at the Medical Faculty of the Otto von Guericke University Magdeburg. The events include interesting guest lectures, hands-on workshops and panel discussions and are fully organized by the students. More information will follow!
Latest News
06/2025
It's good to be back! We were delighted to be part of the 6th conference of Novel Concepts in Innate Immunity (NCII) in Tübingen from June 10-13, 2025. The meeting was absolutely fantastic and the city is lovely. We were thrilled by all the inspiring talks and really enjoyed the fantastic opportunity to network with experts in the field of innate immunity. It wasn't our first visit in Tübingen and it certainly will not be the last one!
05/2025
We are now online! Today we are thrilled to share the news of our latest publication in the Journal of Allergy and Clinical Immunology! The title of our study is 'Ingestion of mast cell granules boosts macrophages and drives atypical programming'. It took a lot of effort, but in the end it was a wonderful and collaborative journey. A huge thank you to all co-authors and colleagues who made this tremendous achievement possible! Now it's time to party!
05/2025
Welcome to the team, Tarek Batakji! We say a warm welcome to Germany and we wish you a wonderful start with your PhD project - we're sure you'll find them a great success!
05/2025
MAPBio - Maladaptive Processes at Physiological Barriers: Insights and Outlooks. This was the topic of the International Symposium from May 5-7, 2025 which was fully organized by the students of the RTG 2408. We had a wonderful time with many fantastic international speakers, e.g. from Portugal or Japan. We were also very grateful to show Prof. Soman Abraham (Duke Universty, North Carolina, USA), Prof. Daniel Dwyer (Harvard University, Boston, USA) and Prof. Christina Zielinski (Friedrich Schiller University, Jena, Germany) the Institue of Molecular and Clinical Immunology. What a great meeting in Magdeburg!
01/2025
The lab is growing again! We have three new group members: two new PhD students and one postdoc. Welcome to the lab, Tanja, Maria and Olga! We wish you a wonderful and successful start and lot's of success with your projects!
12/2024
As the end of the year 2024 approaches, we're looking back on an eventful year. We had some great PhD and master defenses, some awesome international conferences and the welcome of new group members. And we are excited to kick off the new year with even more promising projects and more group members. We'll have more news for you soon!
12/2024
Caution, VENOM! We are thrilled to announce that the student teaching project VENOM has been approaved by the University Teaching Committee. We can't wait to launch some amazing projects next year that will involve the students' active participation.
12/2024
Well done, Patricia! Congratulations on your master's degree. With the successful defense of your thesis, you have officially completed your master’s studies in immunology at the at the Otto-von-Guericke-University in Magdeburg. Wishing you every success in your future endeavors!
11/2024
Congratulations on your successful PhD defense, Dr. Martin Voss! After submitting such an impressive PhD thesis, you also performed excellently in your defense. You've reached a significant milestone and can now close this chapter. The entire team is incredibly proud of you!
09/2024
Thank you, Dr. Johanna Kotrba! After 8 wonderful years in the Dudeck lab, it's time for a new challenge. We look back on an exciting time with several publications, many shared conferences and countless but fruitful scientific discussions. As you take the next step in your career, we wish you all the best and hope you have a great time!
09/2024
Big conference in Ireland: The 7th European Congress of Immunology (ECI) took place in Dublin from September 1st-4th 2024. So many scientist from all over the world, so many great talks and fruitful discussions. While Johanna had a talk in one of the workshops, Konstantinos and Aaron presented their research topics in the poster session. This was a great opportunity again to represent the mast cell research on such a big conference. Well done!
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