Otto-von-Guericke-University Magdeburg
Research Group
Anne Dudeck
Research Group Anne Dudeck
The Dudeck lab explores the intercellular communication of innate immune cells which ensure the first line immune defense and tissue integrity. In different mouse models of inflammatory skin diseases, we study the complex dynamics of tissue resident immune cell responses and cell recruitment processes.
The main focus of our research group is the investigation of mast cells as orchestrators of local inflammatory processes in the skin and their systemic effects. Although mast cells are known to be effector cells of type I allergy, their role in the induction and regulation of innate and adaptive immunity and in maintaining tissue integrity is poorly understood. Our work over the last years has shown that mast cells play an important role as tissue-resident sentinel cells which initiate the innate immune response and can also influence the adaptive defense.
For our work, we apply high-performance methods for both quantitative and qualitative analysis of different immune cell populations, such as elaborate flow cytometry analysis and transcriptomic profiling. In particular, we perform sophisticated imaging analysis, such as intravital 2-photon microscopy and light sheet microscopy of transgenic mouse models, in which certain cells express fluorescent reporter proteins. Most notably, the non-invasive intravital microscopy of the skin enables us to track immune cell motilities and interaction in real time and study the course of an inflammatory response up to tissue regeneration. Moreover, we use mouse models of conditional gene inactivation to decipher the relevance of certain mast cell mediators or signaling compenents.
Latest News
09/2024
Big conference in Ireland: The 7th European Congress of Immunology (ECI) took place in Dublin from September 1st-4th 2024. So many scientist from all over the world, so many great talks and fruitful discussions. While Johanna had a talk in one of the workshops, Konstantinos and Aaron presented their research topics in the poster session. This was a great opportunity again to represent the mast cell research on such a big conference. Well done!
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08/2024
Welcome to the team, Mahsa! We are happy to introduce our new PhD student Mahsa Abedi who started to work in our group in August. Starting from October then, she will be joining the DFG Research Training Group (RTG) 2408. We wish you a wonderful start and a lot of success!
07/2024
We received the tragic news of the loss of our beloved colleague and friend Guido Höbbel with deep sorrow. Guido worked at the Institute of Molecular and Clinical Immunology for many years and he was involved in numerous projects. He was loved by so many people and will always have a place in our heart. Our thoughts are now with his family and his friends.
05/2024
We say hi from the beautiful city of Toulouse! At the 11th European Mast Cell and Basophil Network (EMBRN) Meeting, we came together with our 'family' of the mast cell research. We had lively disussions at the poster sessions and very fruitful conversations with cooperation partners. Additionally, we were able to present our research with a poster (Konstantinos), two talks (Johanna and Aaron) and the closing lecture (Prof. Anne Dudeck). And Aaron even took home the Best Presentation Award. What a successful meeting!
12/2023
Another eventful year is over. Time to have a warm cup of Glühwein at the Magdeburg Christmas market. Cheers!
11/2023
And another successfull PhD defense: Congratulations, Dr. Hanna Edler! You really mastered this final task with flying colors. We are so proud of you and we as a team wish you great success and all the best for the future!
10/2023
This time in Magdeburg: The 3rd Day of Intravital Microscopy took place from 23.-24.10.2023. With lectures and scientific talks addressing intravital microscopy techniques, this meeting was a great opportunity for professional exchange and interaction. Awesome to see and meet so many intravital specialists!
10/2023
It was with great sorrow that we learned of the painful loss of our beloved friend and colleague Mohsen who died far too early. In 2019, Mohsen finished his master thesis in our lab. He was shortly before completion of his excellent dissertation in the lab of Prof. Dr. med. Rüdiger Braun-Dullaeus at the department of cardiology and angiology at the Otto-von-Guericke University Magdeburg. We will keep him in our hearts. Our thoughts are now with his family, his partner and his friends.
09/2023
In September, the joint conference of the Société Française d’Immunologie (SFI) and the Deutsche Gesellschaft für Immunologie (DGfI) took place in Strasbourg. Prof. Anne Dudeck was one of the invited speakers and had the great opportunity to present our research findings in this great atmosphere.
07/2023
You made it, Dr. Kotrba! Congratulations to this great achievment, Johanna. The entire group is so proud of you and we are happy to have a new postdoc in our lab. Hats off!
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