Otto-von-Guericke-University Magdeburg
Research Group
Anne Dudeck
Research Group Anne Dudeck
The Dudeck lab explores the intercellular communication of innate immune cells which ensure the first line immune defense and tissue integrity. In different mouse models of inflammatory skin diseases, we study the complex dynamics of tissue resident immune cell responses and cell recruitment processes.
The main focus of our research group is the investigation of mast cells as orchestrators of local inflammatory processes in the skin and their systemic effects. Although mast cells are known to be effector cells of type I allergy, their role in the induction and regulation of innate and adaptive immunity and in maintaining tissue integrity is poorly understood. Our work over the last years has shown that mast cells play an important role as tissue-resident sentinel cells which initiate the innate immune response and can also influence the adaptive defense.
For our work, we apply high-performance methods for both quantitative and qualitative analysis of different immune cell populations, such as elaborate flow cytometry analysis and transcriptomic profiling. In particular, we perform sophisticated imaging analysis, such as intravital 2-photon microscopy and light sheet microscopy of transgenic mouse models, in which certain cells express fluorescent reporter proteins. Most notably, the non-invasive intravital microscopy of the skin enables us to track immune cell motilities and interaction in real time and study the course of an inflammatory response up to tissue regeneration. Moreover, we use mouse models of conditional gene inactivation to decipher the relevance of certain mast cell mediators or signaling compenents.
COMING UP!
05/2024
Save the date: The European Mast Cell and Basophil Research Network (EMBRN) meeting will take place in Toulouse, France, from May 29 to 31 2024. We are really looking forward to learn about the latest findings in the field of the mast cell and basophil community. Especially, we are happy to announce that Prof. Anne Dudeck will give a talk on May 31! See you in Toulouse!
Latest News
12/2023
Another eventful year is over. Time to have a warm cup of Glühwein at the Magdeburg Christmas market. Cheers!
11/2023
And another successfull PhD defense: Congratulations, Dr. Hanna Edler! You really mastered this final task with flying colors. We are so proud of you and we as a team wish you great success and all the best for the future!
10/2023
This time in Magdeburg: The 3rd Day of Intravital Microscopy took place from 23.-24.10.2023. With lectures and scientific talks addressing intravital microscopy techniques, this meeting was a great opportunity for professional exchange and interaction. Awesome to see and meet so many intravital specialists!
10/2023
It was with great sorrow that we learned of the painful loss of our beloved friend and colleague Mohsen who died far too early. In 2019, Mohsen finished his master thesis in our lab. He was shortly before completion of his excellent dissertation in the lab of Prof. Dr. med. Rüdiger Braun-Dullaeus at the department of cardiology and angiology at the Otto-von-Guericke University Magdeburg. We will keep him in our hearts. Our thoughts are now with his family, his partner and his friends.
09/2023
In September, the joint conference of the Société Française d’Immunologie (SFI) and the Deutsche Gesellschaft für Immunologie (DGfI) took place in Strasbourg. Prof. Anne Dudeck was one of the invited speakers and had the great opportunity to present our research findings in this great atmosphere.
07/2023
You made it, Dr. Kotrba! Congratulations to this great achievment, Johanna. The entire group is so proud of you and we are happy to have a new postdoc in our lab. Hats off!
06/2023
Science for everyone: The Long Night of Science (Lange Nacht der Wissenschaften) is a wonderful event where various research institutes in Magdeburg open their doors for one night to present their daily work to the public. Our Institute of Molecular and Clinical Immunology participated as well. There war great interest in the different projects!
05/2023
Conference of Innate Immunology (NCII) in Tübingen. With severals posters and a talk we presented our latest findings in the study about the role mast cells in inflammation. We met some collegues and had a great time with some old friends. In the evening, we had the chance to explore the beautiful city of Tübingen.
For more information, go to News.